Everything about ceesdekker.net

Everything about ceesdekker.net

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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy approaches, we look for to unravel the mechanistic elements of the composition and dynamics of chromosomes. Our investigation interests consist of:

Human Rad51 filaments on double- and single-stranded DNA: correlating standard and irregular sorts with recombination perform.

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Considering the fact that 2000, Dekker has shifted the key concentration of his work in direction of biophysics where by he research the Homes of one biomolecules and cells utilizing the tools of nanotechnology. This transformation of discipline was pushed by his fascination with the impressive performing of Organic molecular structures, in addition to with the very long-time period standpoint that a lot of intriguing discoveries might be predicted With this industry.[five] Current lines of study in his biophysics group are within the areas of:[6]

We acquire place-of-care diagnostics test of neglected tropical diseases in just source-restricted options, based on Crspr/Cas9 detecting of pathogen’s DNA in system fluids.

Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes

‘At first we looked at biological devices that has a Bodily perspective and acted on The premise on the tools we understood. It took a number of years before we commenced Performing more on the big biological troubles. I then began to call it nanobiology, a term that did not exist at time.

2011, 1st in vitro measurements of transport across a single biomimetic nuclear pore complex; development of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the system of homology recognition in DNA homologous recombination

The rotors harness energy from the nanoscale drinking water and ion movement that is created by a static chemical or electrochemical likely gradient within the nanopore, which are founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and work autonomously in physiological problems, suggesting methods to constructing Vitality-transducing motors at nanoscale interfaces.

There was one issue even though — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule degree, conducting polymers were being basically not such great conductors, which was instead disappointing. cees dekker We Therefore broadened our check out to try to discover a lot more promising molecules.

‘The concept that You can find such a factor being a starting, a major bang, is already an interesting signpost to take into account that there was a creator. But extra generally, and on the basis of pure rationality, I also arrive at a Christian interpretation of reality. An atheistic worldview is actually a naturalistic worldview: basically, you can find only atoms and pure forces that we can easily evaluate.

2001, discovery of single-electron transistors at room temperature according to nanotubes; realization of initial logic circuits with carbon nanotube gadgets; and discovery in the molecular construction of DNA fix enzymes with AFM

Developments in nanotechnology during the nineteen nineties built building Digital devices from one molecules a risk. Cees Dekker recounts how his team created a room-temperature transistor based on a single carbon nanotube.

2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations during the handedness of histone tetrasomes